化合物TAE-1 T21825

Product Introduction
Bioactivity


英文名: TAE-1

描述: TAE-1 是淀粉样蛋白-β 原纤维形成和聚集的抑制剂。它抑制胆碱酯酶 AChE 和 BuChE，IC50 分别为 0.3 μM 和 3.9 μM。

体外活性: The effects of TAE-1 on differentiated human SH-SY5Y neuronal cells grown in tissue culture.?Results showed that the stimulation of neuronal cellular process length and branching was noted.?Moreover, the increased synaptophysin suggested that TAE-1 could stimulate synapse formation.?Increased expression of MAP2 was also observed, indicating that TAE-1 promoted the differentiation of human neurons.?In addition, targeted AChE inhibition was evaluated by electrochemical quantification of the enzymatic product, thiocholine, on unmodified gold screen-printed electrodes.?It was found that at increasing TAE-1concentrations, there was a corresponding decrease in the AChE activity resulting in reduced amount of oxidizable thiocholine.?The IC50 value was found to be 0.465 μM for TAE-1[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 11.29 mg/mL (10 mM)


关键字: β-amyloid peptide | inhibit | TAE 1 | Cholinesterase (ChE) | TAE-1 | Amyloid-β | Abeta | TAE1 | Inhibitor

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相关库: Anti-Neurodegenerative Disease Compound Library | Neurotransmitter Receptor Compound Library | Bioactive Compounds Library Max | Inhibitor Library | NO PAINS Compound Library | Anti-Alzheimer's Disease Compound Library | Bioactive Compound Library

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