化合物BIO-1211 T21868

Product Introduction
Bioactivity


英文名: BIO-1211

描述: BIO-1211 是高度选择性的、口服有效的α4β1 (VLA-4)抑制剂，对 α4β1 和 α4β7 的 IC50分别为 4 nM 和 2 μM。

体外活性: BIO-1211 does not show activity against α1β1, α5β1, α6β1, αLβ2 and αIIbβ3[2].

体内活性: In naive, C57BL/6 mice, BIO-1211 exhibited a considerable depletion in the EAE clinical score, which correlated with decreased expression of TNF-α, IL-17, IFN-γ and pervade of CD11b+ and CD45+ cells into the cerebral cortex. BIO-1211 resulted in reduced cytokines expression, leukocyte trafficking, and inhibition of inflammatory responses in a dose-independent manner[1].

存储条件: keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 250 mg/mL (352.71 mM)


关键字: inhibit | Integrin | BIO1211 | BIO-1211 | BIO 1211 | Inhibitor

相关产品: BMS-688521 | Roxifiban acetate | Bexotegrast | αvβ6 integrin inhibitor 2 | Leukadherin-1 | Cilengitide TFA | E7820 | cRGDfK-thioacetyl ester | OSU-T315 | Egaptivon pegol

相关库: ReFRAME Related Library | Bioactive Compounds Library Max | Inhibitor Library | Peptide Compound Library | Cytoskeletal Signaling Pathway Compound Library | Orally Active Compound Library | Covalent Inhibitor Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途