葛杜宁 T21883

Product Introduction
Bioactivity


英文名: Gedunin

描述: Gedunin 是从印楝种子中提取的一种重要柠檬苦素，具有抗癌、抗病毒、抗炎和杀虫活性。它可阻断 SARS-CoV-2 病毒进入人宿主细胞，用于 COVID-19 研究。它是Hsp90抑制剂，诱导 Hsp90 依赖的蛋白降解，抑制卵巢癌细胞增殖。

体外活性: Gedunin treatment is highly effective in inducing death of pancreatic cancer cells via intrinsic and extrinsic mediated apoptosis.?Gedunin inhibited metastasis of pancreatic cancer cells by decreasing their EMT, invasive, migratory and colony formation capabilities.?Gedunin treatment also inhibited sonic hedgehog signaling pathways.?Further, experiments with recombinant sonic hedgehog protein and Gli inhibitor (Gant-61) demonstrated that gedunin induces its anti-metastatic effect through inhibition of sonic hedgehog signaling.?The anti-cancer effect of gedunin was further validated using xenograft mouse model.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 60 mg/ml (124.33 mM)


关键字: HSP90 | Inhibitor | HSP | Gedunin | Heat shock proteins | inhibit | COVID-19 | Alzheimer's disease | neurodegenerative disorder

相关产品: NCT-58 | JG-98 | BIIB021 | AMP-PCP disodium | Ethoxyquin | PF-04929113 Mesylate | KW-2478 | HM03 | NVP-HSP990 | Gamitrinib TPP hexafluorophosphate

相关库: Anti-Tumor Natural Product Library | Anti-Breast Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Traditional Chinese Medicine Monomer Library | Anti-Cancer Active Compound Library | Natural Product Library for HTS | Metabolism Compound Library | Antiparasitic Natural Product Library | Anti-Viral Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途