(2-巯基乙基)-胍硫酸盐 T21967

Product Introduction
Bioactivity


英文名: MEG hemisulfate

描述: MEG hemisulfate (Mercaptoethylguanidine hemisulfate) 是一种有效和选择性的诱导型 NO 合酶 (iNOS) 的抑制剂，在组织匀浆中抑制 iNOS，ecNOS 和 bNOS 的 EC50 值分别为 11.5，110 和 60 μM。MEG hemisulfate 也有效的过氧亚硝酸盐清除剂，可抑制过氧亚硝酸盐诱导的氧化过程。MEG hemisulfate 在许多炎症实验模型中具有保护作用，包括缺血/再灌注损伤，牙周炎，失血性休克，炎性肠病以及内毒素和败血性休克。

体外活性: MEG (0.1-1000 μM; 18 h) reduces nitrite accumulation in the supernatant of cultured J774.2 macrophages activated with LPS (10 μg/mL) and INF (50 μg/mL). MEG inhibits iNOS activity in homogenates of lungs taken from LPS-treated rats[1]. MEG (1 μM-3 mM; 3 min) dose-dependently inhibits the peroxynitrite-induced oxidation of cytochrome c2+ and hydroxylation of benzoate. MEG (1-300 μM) inhibits the suppression of mitochondrial respiration and DNA single strand breakage in response to peroxynitrite in J774 cells. MEG (300 μM; 30 min) inhibits the suppression of vascular contractility in response to peroxynitrite in thoracic aortic rings[2].

体内活性: MEG (30-60 mg/kg; a single i.p.) decreases mean arterial blood pressure (MAP) of normal rats[1]. MEG (10 mg/kg; i.p. for 5 d) attenuates the degree of lipid peroxidation, protein oxidation, and peroxynitrites level and ameliorated the decrease of antioxidant enzymes activities in the esophagus of rats subjected to caustic burn injury[3]. MEG (10 mg/kg; a single i.p.) improves the renal dysfunction and tissue injury induced by ischemia/reperfusion (I/R) of rat kidney[4].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 45 mg/mL (133.75 mM)


关键字: Mercaptoethylguanidine Hemisulfate | MEG | MEG Hemisulfate | Mercaptoethylguanidine

相关产品: AICAR phosphate | 1-Hydroxy-2,3,5-trimethoxyxanthone | Nyasol | 6-Dehydrogingerdione | Negletein | Tuberosin | Bakkenolide B | Sinapyl alcohol | Shizukaol B | 3,4-O-Isopropylidene-shikimic acid

相关库: Bioactive Compounds Library Max | Inhibitor Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途