化合物Phthalazinone pyrazole T21981

Product Introduction
Bioactivity


英文名: Phthalazinone pyrazole

描述: Phthalazinone pyrazole 是强效、选择性和口服生物可利用的 Aurora-A 激酶抑制剂，IC50值为 0.031 μM。它抑制人胚胎干细胞向肝细胞样细胞分化过程中的上皮间质转化。它还可阻止有丝分裂并随后通过增殖细胞的凋亡抑制肿瘤生长。

体外活性: Phthalazinone pyrazole potently inhibited the activity of Aurora A kinase with an IC50 of 31 nM. It showed no inhibitory effect on Aurora B kinase at doses up to 100 μM. Phthalazinone pyrazole inhibited the proliferation of HCT116, Colo205, and MCF-7 cells with IC50 values of 7.8, 2.9, and 1.6 μM, respectively [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : Slightly soluble


关键字: inhibit | human embryonic stem cells | Aurora Kinase | hepatocyte-like cell | Inhibitor | HLCs | Aurora-A kinase | EMT | apoptosis | Phthalazinone pyrazole | tumor growth | oral | epithelial-mesenchymal transition

相关产品: SP-146 | Palmatine | MBM-17 | MBM-17S | CCT241736 | KW-2449 | GW779439X | Centrinone-B | Palmatine chloride | GW843682X

相关库: Cell Cycle Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Kinase Inhibitor Library | Epigenetics Compound Library | Anti-Cancer Active Compound Library | Orally Active Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途