化合物 T22230 T22230

Product Introduction
Bioactivity


英文名: Acotiamide

描述: Acotiamide 是一种具有口服活性、选择性和可逆性的乙酰胆酶碱酯 (AChE) 抑制剂，IC50值为1.79 μM。Acotiamide 是一种胃促动力剂，可增强胃收缩性并加速胃排空延迟。Acotiamide 可用于胃动力障碍的功能性消化不良及肠道炎症的研究。

体外活性: Acotiamide (10, 30, 100 μM; 1 hour) decreases expression levels of IκB-α phosphorylation in LPS- and MCP-1-stimulated macrophage cell lines [1]. Cell Viability Assay [1] Cell Line: NR8383, macrophage Concentration: 10, 30, 100 μM Incubation Time: 1 hour Result: Significantly reduced both TNF-α and IL-6 productions in LPS/MCP-1-stimulated NR8383 cells.

体内活性: Acotiamide (0.3, 1, 3 mg/kg; i.v./3, 10, 30 mg/kg; p.o.) increases the index of postprandial gastric motility in a dose-dependent manner [2]. Acotiamide (0.83 mg/kg; i.v.; once) inhibits AChE in rat stomach with IC 50 of 1.79 μM [3]. Animal Model: Male mongrel dogs (9-11 kg), Male beagle dogs (9.6-12.9 kg) [2] Dosage: 0.3, 1, 3, 10, 30 mg/kg Administration: Intravenous injection; once Result: Increased the postprandial gastric motility. Animal Model: Male Sprague-Dawley rats (aged 6-7 weeks) [3] Dosage: 0.83 mg/kg Administration: Intravenous injection; once. Result: Effectively improved functional dyspepsia by inhibiting AChE in rat stomach.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Acotiamide

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途