双(麦芽醇)氧钒(IV) T22276

Product Introduction
Bioactivity


英文名: Bis(maltolato)oxovanadium(IV)

描述: Bis(maltolato)oxovanadium(IV) (BMOV) 是一种有效的胰岛素增敏剂，也是一种有效的、竞争性的、可逆的、口服具有活性的光谱蛋白酪氨酸磷酸酶 (PTP) 抑制剂。它抑制HCPTPA，PTP1B，HPTPβ和SHP2的IC50分别为 126 nM，109 nM，26 nM 和 201 nM。

动物实验: BMOV (0.75-3.0 mmol; intraperitoneal injection; twice weekly; for 6 weeks; Male C57BL/6J mice) treatment ameliorates the metabolic phenotype, as evidenced by reduced body weight, improved insulin sensitivity and glucose tolerance.

体外活性: BMOV treatment enhances the phosphorylation of the insulin receptor and of the insulin signalling key intermediate Akt. BMOV treatment also resultes in an increased glucose uptake in C2C12 cells[1].

体内活性: BMOV (0.75-3.0 mmol; intraperitoneal injection; twice weekly; for 6 weeks; Male C57BL/6J mice) treatment ameliorates the metabolic phenotype, as evidenced by reduced body weight, improved insulin sensitivity and glucose tolerance.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 20 mg/mL (63.06 mM)


关键字: type-2 | Phosphatase | inhibit | SHP2 | Inhibitor | phenotype | metabolic | Bis(maltolato)oxovanadium | SHP-1 | HCPTPA | uptake | glucose | HPTPβ | insulin | PTP | PTP1B | diabetes | Bis(maltolato)oxovanadium(IV)

相关产品: DT-061 | NSC 95397 | Cyt-PTPε Inhibitor-1 | Boehmenan | PROTAC PTPN2 degrader-2 | Raphin1 acetate | TD52 | Rbin-2 | Voclosporin | JAB-3068

相关库: Glycometabolism Compound Library | ReFRAME Related Library | Bioactive Compounds Library Max | Phosphatase Inhibitor Library | Inhibitor Library | Metabolism Compound Library | Orally Active Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途