化合物DTP3 T22319

Product Introduction
Bioactivity


英文名: DTP3

描述: DTP3 是一种选择性 MKK7/GADD45β 抑制剂，靶向 NF-κB 通路，可抑制癌症。

体外活性: DTP3 physically interacts with MKK7 in isolation and within the complex with GADD45β, and dissociates the GADD45β/MKK7 complex via an allosteric mechanism. DTP3 selectively kills cells and induces apoptosis in MM cells with functional MKK7 and elevated GADD45β expression without toxicity to normal cells. In addition, DTP3 displays synergistic activity with bortezomib in two different MM cell lines, exhibiting a combination index of 0.56 in KMS-12 cells and of 0.21 in U266 cells. [1]

体内活性: DTP3以14.5 mg/kg/day的剂量对鼠类骨髓瘤模型中的多发性骨髓瘤（MM）展示出强大的抗肿瘤活性。[1]

存储条件: keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 100 mg/ml (190.26 mM)
H2O : 100 mg/ml (190.26 mM)
DMSO : 100 mg/ml (190.26 mM)


关键字: cancer | DTP3 | inhibit | Inhibitor | Janus kinase | DNA/RNA Synthesis | DTP 3 | NF-κB | tumor | GADD45β | DTP-3 | JAK

相关产品: Moloney murine leukemia virus RT | Capillarisin | L-Methioninamide hydrochloride | Ro5-3335 | Gallium maltolate | Trifluridine | Beaucage reagent | Filibuvir | Supinoxin | Cisplatin

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途