甲哌卡因 T22361

Product Introduction
Bioactivity


英文名: Mepivacaine

描述: Mepivacaine (Carbocaine) 是一种可用于局部麻醉的酰胺类化合物，可使人或动物短暂的失去自知觉。Mepivacaine 通过与神经细胞膜上特定的电压门控钠离子通道结合，抑制钠离子内流和膜去极化来发挥作用。Mepivacaine 适用于神经阻滞和硬膜外麻醉。

体外活性: Mepivacaine 表现出对 Na(v)1.8 通道的使用依赖性阻断，而 S(-)-bupivacaine 则偏好于 TTX-敏感的 Na(+) 通道。[2]

体内活性: Intratesticular mepivacaine (10 mL ; injection) when compared with intratesticular lidocaine results in improved cremaster muscle relaxation when only waiting five min prior to the start of the procedure.[2]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 30.0 mg/mL (121.8 mM )


关键字: Mepivacaine

相关产品: DS-1971a | Dibucaine | Ralfinamide mesylate | GTx1-15 | QX-314 chloride | Articaine hydrochloride | Halofuginone hydrobromide | N-Acetylprocainamide | Jingzhaotoxin-II | Sodium Channel inhibitor 4

相关库: Drug Repurposing Compound Library | Approved Drug Library | FDA-Approved & Pharmacopeia Drug Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Approved Drug Library | EMA Approved Drug Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途