1,3,5-三缩水甘油-S-三嗪三酮 T22443

Product Introduction
Bioactivity


英文名: Triglycidyl isocyanurate

描述: Triglycidyl isocyanurate (Teroxirone) 是一种三氮烯三环氧化合物，可通过 p53的激活抑制非小细胞肺癌细胞的生长。它诱导细胞凋亡，具有抗血管生成和抗肿瘤活性，用于癌症研究。

细胞实验: Triglycidyl isocyanurate (0-30 μM; 48?hours) Inhibited tumor cells(A549, H460 and H1299 cells)growth in soft agar. Triglycidyl isocyanurate (0-30 μM; 48?hours) inhibited akt1/2/3 expression and p-aktser473/474/472 expression of A549, H460 and H1299 tumorspheres.

动物实验: Triglycidyl isocyanurate (Female nu/nu mice with Huh7 cells subcutaneously injected into the dorsal area; 1.8 and 3.6 mg/kg; every 2–3 days for total seven times; 30 days)Inhibited the growth of xenograft tumors[2].

体外活性: Triglycidyl isocyanurate (0-30 μM; 48?hours) inhibits expression of akt1/2/3 and phosphorylated Aktser473/474/472 of A549, H460 and H1299 tumorspheres, however, the cleavage of PARP and procaspase-3 plus the emergent active caspase-3 fragment are only visible in H460 and A549 tumorspheres[1]. Triglycidyl isocyanurate (0-30 μM; 48?hours) reduces the growth of spheroids of human non-small-cell-lung cancer cells in culture, it leads to a gradual reduction in size for tumorspheres of A549, H460 and H1299 cells[1].

体内活性: Triglycidyl isocyanurate (subcutaneous injection; 1.8 and 3.6 mg/kg; every 2–3 days for total seven times; 30 days) suppresses the growth of xenograft tumors without effect on weight in nude mice[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (168.2 mM)


关键字: Triglycidyl isocyanurate | hepatocellular | Apoptosis | Hep3B | Inhibitor | HCC | tumor | inhibit | anticancer agent | liver cancer | carcinoma | NSCLC | HepG2 | MDM-2/p53

相关产品: Merodantoin | SCH79797 dihydrochloride | PD173955 | CA-5f | Quercetin Dihydrate | Ac-​IETD-​CHO | Dihydrokaempferol | WHI-P154 | NSC 146109 hydrochloride | B-AP15

相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Anti-Colorectal Cancer Compound Library | Anti-Cancer Active Compound Library | Apoptosis Compound Library | PPI Inhibitor Library | Anti-Pancreatic Cancer Compound Library | Covalent Inhibitor Library | NO PAINS Compound Library | Bioactive Compound Library

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