ATC 0175 盐酸盐 T22591

Product Introduction
Bioactivity


英文名: ATC 0175 hydrochloride

描述: ATC 0175 hydrochloride 是一种具有口服活性的黑色素细胞浓缩激素1受体拮抗剂，具有强效性和选择性，ATC 0175 hydrochloride 对MCH1R、MCH2R、MCH1、5-HT2B 受体和5-HT1A 受体 具有亲和力 ，IC50分别为为13.5nM、>10,000 nM、13 nM、9.66 nM 和16.9 nM。ATC 0175 hydrochloride 在动物模型中表现出抗抑郁和抗焦虑作用。ATC0175可用于研究抑郁症和/或焦虑症。

体外活性: In vitro, assays showed that this compound is a potent antagonist with a high affinity for MCH1R. The receptor binding and the functional assay (MCH-induced increase in [Ca2+]) indicated that ATC0175 is a noncompetitive antagonist at MCH1Rs.[1]

体内活性: ATC0175 (1, 3, 10 mg/kg ; p.o. ) treatment also exhibited antidepressant effects in the forced swimming test.[2] ATC0175 displayed anxiolytic effects in numerous animal models of anxiety including the social interaction test, elevated plus-maze test, maternal separation-induced vocalization and stress-induced hyperthermia.[2]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 22.5 mg/mL (48.7 mM)
DMSO : 9.0 mg/mL (19.4 mM)


关键字: ATC-0175 Hydrochloride | ATC 0175 hydrochloride | ATC 0175 Hydrochloride | ATC0175 Hydrochloride

相关产品: MK-7246 | 1-methoxycyclopropanecarboxylic acid | Latanoprost acid | Dehydroeffusol | CID 2745687 | NE 52-QQ57 | Ramatroban | ML192 | Kynurenic acid | Lodoxamide

相关库: Neurotransmitter Receptor Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | GPCR Compound Library | Anti-Obesity Compound Library | Bioactive Compound Library

ATC 0175 盐酸盐 T22591信息由TargetMol中国为您提供，如您想了解更多关于ATC 0175 盐酸盐 T22591报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途