反-曲尼司特 T2270

Product Introduction
Bioactivity


英文名: Trans-Tranilast

描述: Trans-Tranilast 是抗过敏剂，可用于过敏性鼻炎、支气管哮喘和特应性皮炎的研究。

体内活性: Protodioscin (5 and 10 mg/kg) significantly improves glucose intolerance and reduced the levels of serum UA, BUN, Cr, TC and TG. Protodioscin significantly reduces renal concentrations of IL-1β, IL-6 and TNF-α by inhibiting the activation of nuclear factor-κB, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase and extracellular signal-regulated kinase[1]. Protodioscin ameliorates the death rate, inhibits the increase in neurological deficit scores and infarct volume, and reduces the apoptotic nerve cells induced by MCAO in rats. Protodioscin attenuates the change of relevant apoptins, suppresses the release of pro-inflammatory cytokines in serum and reverses the protein expression of NF-κB (in nucleus and cytoplasm) and IκBα (in cytoplasm) induced by MCAO in rats[2]. Protodioscin (0.5?mg/kg, i.p.) increases the coagulation time by appr?50?% as compared to that of high-fat diet control rats. Protodioscin possesses a promising effect in lowering the blood levels of both lipoproteins, especially LDL, thus resulting in a high ratio of HDL/LDL[3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 60 mg/mL (183.3 mM)


关键字: Trans Tranilast | trans-SB 252218 | Inhibitor | Angiotensin Receptor | TransTranilast | trans-Tranilast | inhibit | Trans-Tranilast

相关产品: Azilsartan Medoxomil | Ripisartan | Prosaikogenin G | Leucylarginylproline | Angiotensin 1/2 (5-7) acetate | DX600 TFA | Tranilast | Azilsartan Methyl Ester | TRV-120027 TFA | Quinapril hydrochloride

相关库: Drug Repurposing Compound Library | Approved Drug Library | ReFRAME Related Library | Angiogenesis related Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Endocrinology-Hormone Compound Library | NO PAINS Compound Library | Covalent Inhibitor Library | Anti-Cardiovascular Disease Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途