化合物LY266097盐酸盐 T22947
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 mg | 172895-39-5 | ¥2,470.00 | 询底价 |
1 mg | 172895-39-5 | ¥217.00 | 询底价 |
5 mg | 172895-39-5 | ¥693.00 | 询底价 |
100 mg | 172895-39-5 | ¥3,520.00 | 询底价 |
1 mL | 172895-39-5 | ¥687.00 | 询底价 |
10 mg | 172895-39-5 | ¥1,060.00 | 询底价 |
25 mg | 172895-39-5 | ¥1,660.00 | 询底价 |
500 mg | 172895-39-5 | 面议 | 询底价 |
Product Introduction
Bioactivity
英文名: LY266097 hydrochloride
描述: LY266097 hydrochloride (LY 266097 hydrochloride) 是 5-HT2 的拮抗剂,对人 5-HT2A、5-HT2B 和 5-HT2C 的 pKis 分别为 7.7、9.8 和 7.6,可用于抑郁症研究。
体内活性: In vivo electrophysiological recordings of ventral tegmental area (VTA) dopamine (DA) neurons, dorsal raphe nucleus (DRN) 5-HT neurons and pyramidal neurons in the medial prefrontal cortex (mPFC), and the hippocampus were conducted in anaesthetized Sprague-Dawley rats after the administration of 5-HT2B receptor ligands alone or in combination with the SSRI escitalopram. An escitalopram-induced decrease in DA, but not 5-HT firing activity, was rescued by 2-day co-administration of the selective 5-HT2B receptor antagonist LY266097. In the mPFC, 14-day escitalopram administration alone had no effect on pyramidal neuron firing and burst activity, whereas, aripiprazole administered alone or in combination with escitalopram for 14 days increased pyramidal neuron firing and burst activity. Likewise, the administration of LY266097 alone or its addition on the last 3 days of a 14-day escitalopram regimen increased pyramidal neuron firing and burst activity[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 56.2 mg/mL (138.1 mM)
关键字: LY 266097 Hydrochloride | LY-266097 hydrochloride | LY266097 hydrochloride | LY-266097 Hydrochloride | LY266097 Hydrochloride
相关产品: Pirenperone | Tandospirone | Gepirone | Cericlamine | Cyclobenzaprine hydrochloride | 2-Methyl-5-HT | Desmethyl cariprazine | Seganserin | 5-HT6/7 antagonist 1 | LY334370
相关库: Neurotransmitter Receptor Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | GPCR Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途