化合物ML SA1 T23004

Product Introduction
Bioactivity


英文名: ML-SA1

描述: ML-SA1 (Mucolipin synthetic agonist 1) 是一种选择性的TRPML 激动剂，通过促进溶酶体的酸化和蛋白酶活性抑制登格病毒 2 和寨卡病毒，抗 DENV2 RNA 和 ZIKV RNA 的IC50分别为 8.3 μM 和 52.99 μM。ML SA1可诱发自噬。ML SA1可用于广谱抗病毒研究。

体外活性: ML-SA1 (25 μM; 0~14 hours; A549 cells) possibly affects the entry of DENV2 into host cells[1].ML-SA1 (0~200 μM; A549 cells) shows that there is no cytotoxicity to the cell line observed, even at concentrations up to 200 μM. ML-SA1 (0~50 μM; A549 cells) significantly suppresses DENV2 at the RNA levels and the IC50 is 8.93 μM[1]. ML-SA1 results in a dose-dependent decrease in ZIKV in A549 cells at both the RNA and protein levels, and the IC50 value of ML-SA1 against ZIKV RNA is 52.99 μM. ML-SA1, as an activator of TRPMLs, appears to be a potent inhibitor of DENV2 and ZIKV in vitro. ML-SA1 promotes lysosomal acidification and protease activity to inhibit viral infection. ML-SA1 can induce autophagy in Huh7 cells or A549 cells[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 17 mg/mL (46.90 mM)


关键字: lysosomal | ML SA1 | Inhibitor | inhibit | protease | Transient receptor potential channels | autophagy | broad-spectrum | selective | acidification | Zika | MLSA1 | ML-SA-1 | antiviral | TRP Channel | virus | ML-SA1 | Dengue

相关产品: RN-1665 | Podocarpic acid | TRPM4 inhibitor 8 | AMG2850 | SB 452533 | AM12 | Dihydromorin | Camphor | ML329 | AMG 333

相关库: Ion Channel Inhibitor Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | NO PAINS Compound Library | Anti-Viral Compound Library | Bioactive Compound Library | Anti-Infection Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途