化合物MMPIP hydrochloride T23008L

Product Introduction
Bioactivity


英文名: MMPIP hydrochloride

描述: MMPIP hydrochloride 是变构 mGluR7 的选择性拮抗剂。 MMPIP hydrochloride 可用于研究 mGluR7 对中枢神经系统功能的作用。

体外活性: In CHO cells coexpressing rat mGluR7 with Gα15, MMPIP hydrochloride inhibits L-(+)-2-amino-4-phosphonobutyric acid (L-AP4; 0.5 mM)-induced intracellular Ca2+ mobilization with an IC50 of 26 nM. MMPIP hydrochloride also antagonizes L-AP4-induced inhibition of cAMP accumulation with an IC50 of 610 nM. MMPIP hydrochloride inhibits L-AP4-induced inhibition of forskolin-stimulated cAMP accumulation in CHO cells expressing rat mGluR7[1].

体内活性: MMPIP hydrochloride alleviates pain and normalizes affective and cognitive behavior in neuropathic mice. MMPIP hydrochloride (10 mg/kg; i.p.) rescues the MK-801 (0.1 mg/kg)-induced cognitive impairments, by improving the choice accuracy. MMPIP hydrochloride (10 mg/kg) attenuates the amplitude of the acoustic startle response and markedly enhances the prepulse-induced inhibition of the acoustic startle response (up to 137% of control)[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 3.7 mg/mL (10 mM)


关键字: 479077-02-6 | MMPIP Hydrochloride | MMPIP hydrochloride | MMPIP | system | nervous | neuropathic | behavior | pain | inhibit | central | glutamate | cognitive | allosteric | Metabotropic glutamate receptors | 479077-02-6 Free base | Inhibitor | metabotropic | mGluR | mGluR7

相关产品: Harmine hydrochloride | Philanthotoxin 74 dihydrochloride | DCB | CBiPES hydrochloride | TCN238 | VU0360172 | CX614 | LY341495 | trans-ACPD | LY 541850

相关库: Anti-Neurodegenerative Disease Compound Library | Neurotransmitter Receptor Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Inhibitor Library | Bioactive Compound Library

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