化合物SR 11302 T23384

Product Introduction
Bioactivity


英文名: SR 11302

描述: SR 11302 是一种类视黄醇，是一种激活蛋白-1 转录因子抑制剂，能够特异性抑制 AP-1 活性，而不会激活视黄酸反应元件 (RARE) 的转录。

体外活性: SR 11302能夠抑制乳腺癌細胞系T-47D、肺癌細胞系Calu-6和HeLa細胞的生長。对于HL-60、新鲜的APL和NB4細胞的增殖或分化，SR 11302則几乎没有影响[2]。

体内活性: In an AP-1-luciferase transgenic mouse carcinogenesis model, SR11302 significantly inhibits both AP-1 activations in 7,12-dimethyl benz(a)anthracene-initiated mouse skin and 12-O-tetradecanoylphorbol-13-acetate-induced papilloma formation[3].

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/Ml(132.79 mM)


关键字: acid | retinoid | Lung | RARE | Cancer | SR11302 | SR 11302 | response | Inhibitor | protein-1 | SR-11302 | inhibit | AP-1 | retinoic | element | activator

相关产品: Moloney murine leukemia virus RT | Vitamin D2 | 3'-Deoxy-3'-fluoroguanosine | Sodium Camptothecin | APE1-IN-1 | S-Adenosyl-L-methionine disulfate tosylate | COH1 | TH287 hydrochloride | COH29 | 2'-Deoxyadenosine-5'-triphosphate

相关库: Cell Cycle Compound Library | Transcription Factor-Targeted Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | DNA Damage & Repair Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途