磺基舒林 T23403

Product Introduction
Bioactivity


英文名: Sulindac sulfone

描述: Sulindac sulfone 是非甾体抗炎药舒林酸 (sulindac) 的代谢物。 它是醛糖还原酶的抑制剂 (IC50 =367 nM)。

体外活性: In vitro: Sulindac sulfone treatment also inhibited PGE2 production by HCA-7 cells with an IC50 of 360 mmol/L. Sulindac sulfone at 100 mmol/L reduced 6-ketoPGFα by 29.2%. Sulindac sulfone reduced the colony number of HCA-7 and HCT-116 with an EC50 of 50 mmol/l. Sulindac sulfone significantly decreased the expression of total cellular β-catenin (50% of control), pro-caspase 3 (49%), cyclin D1 (51%), and PPARδ (65%) in SW480 cells. No significant alteration in pro-caspase 3 or β-catenin expression was found in HCA7, LS174, or Caco-2 cells treated with sulindac sulfone. A dose-dependent reduction in TCF-mediated transcriptional activity was also observed in SW480 cells [1][2].

体内活性: 体内研究：Sulindac sulfone 能够在大鼠的 azoxymethane (AOM) 结肠癌模型中降低发病率、多发性以及肿瘤负担。而对 HCA-7、HCT-116 异种移植瘤和癌细胞异种移植瘤的生长无影响[1]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : < 2.54 mg/mL
DMSO : > 9.53 mg/mL
Ethanol : > 3.83 mg/mL


关键字: Aldose Reductase | Sulindac sulfone | inhibit | Exisulind | Inhibitor

相关产品: Turosteride | Alpha-Estradiol | Danshenol A | Isoliquiritigenin | Poliumoside | Sorbinil | ALR2-IN-1 | DL-Glyceraldehyde | Dutasteride | 12-O-Methylcarnosic acid

相关库: Anti-Aging Compound Library | Drug Repurposing Compound Library | Anti-Prostate Cancer Compound Library | Anti-Cancer Drug Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Clinical Compound Library | Anti-Colorectal Cancer Compound Library | Anti-Cancer Active Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途