化合物STF-31 T2363

Product Introduction
Bioactivity


英文名: STF-31

描述: STF31 是一种葡萄糖转运蛋白 1 的选择性抑制剂，IC50为 1 μM。

体外活性: STF-31 selectively kills RCCs by specifically targeting glucose uptake through GLUT1. STF-31 significantly inhibits lactate production and extracellular acidification in VHL-deficient cells by about 60%, and decreases glycolysis by decreasing glucose transport. [1] In NAPRT1-expressing cells, STF-31 shows cytotoxicity by inhibiting the enzymatic activity of NAMPT. [2] STF-31 is toxic to hPSCs and efficient for selective elimination of hPSCs from mixed cultures. [3]

体内活性: In mice with VHL-deficient RCC xenografts, a more soluble analog of STF-31 (11.6 mg/kg, i.p.) markedly delays tumor growth. [1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 25 mg/mL (59.03 mM)
DMSO : 42.4 mg/mL(100 mM)


关键字: VHL | inhibitor | RCC4/VHL | Autophagy | STF-31 | STF31 | GLUT | Glucose transporter | GLUT1 | inhibit | glucose | RCC4 | STF 31

相关产品: Procyanidin A2 | Fasentin | Telaglenastat | Dodoviscin I | Dodoviscin A | Glutaminase-IN-1 | WZB117 | Nepodin | GT 949 | WAY-213613

相关库: Anti-Aging Compound Library | Glycometabolism Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Cancer Compound Library | Anti-Metabolism Disease Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Active Compound Library | Autophagy Compound Library | NO PAINS Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途