化合物Rociletinib T2369
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
5 mg | 1374640-70-6 | ¥415.00 | 询底价 |
10 mg | 1374640-70-6 | ¥679.00 | 询底价 |
50 mg | 1374640-70-6 | ¥1,246.00 | 询底价 |
100 mg | 1374640-70-6 | ¥1,997.00 | 询底价 |
1 mL | 1374640-70-6 | ¥498.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Rociletinib
描述: Rociletinib (CNX-419) 是一种可口服的EGFR 抑制剂,能够抑制 EGFRL858R/T790M 和 EGFRWT 的活性,IC50值分别为 21.5 nM 和 303.3 nM。
细胞实验: Cells are seeded at 3,000 cells per well in growth media supplemented with 5% FBS, 2 mmol/L, L-glutamine, and 1% penicillin–streptomycin, allowed to adhere overnight, and treated with a dilution series of test compounds for 72 hours. Cell viability is determined by CellTiter-Glo, and results are represented as background-subtracted relative light units normalized to a dimethyl sulfoxide (DMSO)–treated control. Growth inhibition (GI 50) values are determined by GraphPad Prism 5.04. MK-2206 and XL-880 compounds are obtained from Selleck Chemical. CI data are generated using CalcuSyn.(Only for Reference)
激酶实验: Inhibition Kinetics Studies: Recombinant human wild-type and T790M/L858R double mutant EGFR, both Nterminal GST-tagged, are used in the assay. The Omnia continuous read assay is performed as described by the vendor.
体外活性: CO-1686在所有EGFR突变体模型以及表达EGFRL858R-和EGFRL858R/T790M的转基因小鼠中引起显著的剂量依赖性肿瘤生长抑制.
体内活性: CO-1686选择性抑制NSCLC细胞表达的突变体EGFR的生长,GI50范围为7 到 32 nM,并诱导细胞凋亡。耐CO-1686的NSCLC细胞系表现出上皮 - 间充质转变的迹象并且对AKT抑制剂的敏感性增加。CO-1686在表达突变型EGFR的细胞中抑制p-EGFR,其IC50范围为62至187 nM,同时在三种WT EGFR表达细胞中抑制EGFR磷酸化,IC50> 2,000 nM。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: Ethanol : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 93 mg/mL (167.4 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
关键字: CNX 419 | AVL 301 | HER1 | Inhibitor | inhibit | CO 1686 | EGFR | ErbB-1 | Rociletinib | AVL301 | CNX419 | Epidermal growth factor receptor | CO1686
相关产品: Methyl 2,5-dihydroxycinnamate | AG-1478 | EGFR/CSC-IN-1 | OK2 | EGFR-IN-11 | Brigatinib | Cisapride hydrate | EBE-A22 | Dacomitinib hydrate | Lidocaine Hydrochloride hydrate
相关库: Drug Repurposing Compound Library | FDA-Approved Kinase Inhibitor Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Inhibitor Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Highly Selective Inhibitor Library | Anti-Cancer Active Compound Library | Anti-Cancer Approved Drug Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途