马来酸匹衫琼 T2394

Product Introduction
Bioactivity


英文名: Pixantrone dimaleate

描述: Pixantrone dimaleate (Pixantrone Maleate) 是一种拓扑异构酶 II 的抑制剂和 DNA 嵌入剂，是一种实验性抗肿瘤药物。

激酶实验: Recombinant RT enzymes are expressed, purified, and assessed for inhibition by Efavirenz (L-743726). Ki and Kii values are determined for each enzyme tested. The wild-type RT exhibited exclusively noncompetitive inhibition kinetics (data not shown), and, therefore, the Ki and Kii values are identical. Pure noncompetitive inhibition is not assumed for the mutant enzymes, and, hence, the values of both Ki and Kii are obtained from the linear mixed-type inhibition equation. The two- to threefold differences between the Ki and Kii values probably reflect a small contribution of competitive inhibition with the mutant RTs[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 91 mg/mL(163.3 mM)


关键字: Topoisomerase | K562 cell | Pixantrone dimaleate | BBR 2778 | inhibit | Inhibitor | intercalator | MDCK cell | Pixantrone Dimaleate | Pixantrone | BBR2778 Dimaleate | BBR-2778 Dimaleate | anti-tumor | BBR 2778 Dimaleate | BBR2778 | DNA

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相关库: Drug Repurposing Compound Library | Approved Drug Library | ReFRAME Related Library | Anti-Cancer Drug Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Approved Drug Library | Anti-Cancer Active Compound Library | EMA Approved Drug Library | Target-Focused Phenotypic Screening Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途