化合物ERDRP-0519 T24040

Product Introduction
Bioactivity


英文名: ERDRP-0519

描述: ERDRP-0519是一种口服可用的小分子抑制剂，针对麻疹病毒(MeV)聚合酶。它在松鼠猴(Saimiri sciureus)中有效预防麻疹病，并在纳摩尔范围内展现出对棘皮动物病毒的强大抑制作用。

体外活性: ERDRP-0519 exhibits potency against a panel of Measles virus (MeV) isolates with EC50s of 0.07- 0.3 µM[1]. ERDRP-0519 exhibits potency against MeV and related pathogens of the Morbillivirus genus, such as canine distemper virus (CDV)[3].

体内活性: A single-dose pharmacokinetic (PK) study is performed in squirrel monkeys by oral (intragastric) delivery of ERDRP-0519 (50 mg/kg) and blood sampling at seven predefined time points after dosing. Serum concentrations peak ~2 h post-administration (Cmax=3.27 µM)[3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 90 mg/mL (169.9 mM)


关键字: ERDRP-0519

相关产品: MK-28 | Cynarin | Seselin | Brincidofovir | Alovudine | IND24 | Tirilazad mesylate | Didemnin B | Somantadine | 6'-O-Galloylsalidroside

相关库: Bioactive Compounds Library Max | Inhibitor Library | Anti-Viral Compound Library | Bioactive Compound Library

化合物ERDRP-0519 T24040信息由TargetMol中国为您提供，如您想了解更多关于化合物ERDRP-0519 T24040报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途