噻加宾 T2407

Product Introduction
Bioactivity


英文名: Tiagabine

描述: Tiagabine (NO050328) 是具有抗惊厥特性的选择性 GABA 再摄取抑制剂，在突触体、神经元和神经胶质中，能够抑制 [3H]GABA 的重摄取，IC50值分别为 67、446 和 182 nM。

体外活性: Tiagabine is a potent inhibitor of GABA uptake into neurons and glial cells. It is involved in modulating GABA levels, especially in areas such as the hippocampus and thalamus[2]. Tiagabine not only affected the decay kinetics of the IPSCs, it also reduced the frequency of occurrence of both spontaneous and miniature IPSCs[1].

体内活性: Tiagabine offers a significant neuroprotection in global ischemia in gerbils when given 30 min before ischemia but not when given 3 h after ischemia[3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 10 mg/mL (26.63 mM)


关键字: NO 050328 | Gamma-aminobutyric acid Receptor | Inhibitor | Tiagabine | inhibit | γ-Aminobutyric acid Receptor | NO-328 | GABA Receptor | NO 328 | NO-050328

相关产品: CP-409092 | SCS | Loreclezole | Baicalin | (-)-Securinine | Isohyenanchin | Jujuboside A | 6-Hydroxyflavone | Apalutamide | Tracazolate hydrochloride

相关库: Anti-Neurodegenerative Disease Compound Library | Drug Repurposing Compound Library | Approved Drug Library | Neurotransmitter Receptor Compound Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途