伊奈骨化醇 T24166
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mg | 163217-09-2 | ¥14,900.00 | 询底价 |
1 mL | 163217-09-2 | ¥14,800.00 | 询底价 |
25 mg | 163217-09-2 | ¥22,500.00 | 询底价 |
50 mg | 163217-09-2 | ¥29,700.00 | 询底价 |
5 mg | 163217-09-2 | ¥11,200.00 | 询底价 |
1 mg | 163217-09-2 | ¥5,390.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Inecalcitol
描述: Inecalcitol (TX 522) 是一种独特的维生素 D3 类似物,可诱导细胞凋亡,有抗癌活性。它是一种具有口服活性维生素 D 受体激动剂,Kd 为 0.53 nM。
体外活性: A xenograft model of LNCaP cells was developed in immunodeficient mice treated with inecalcitol. The tumors of the diluent-treated control mice increased in size but those in the inecalcitol treatment group did not grow[1].
体内活性: Inecalcitol maximal tolerated dose (MTD) by intraperitoneal (i.p.) administration was 30 μg/mouse (1,300 μg/kg) three times per week, while we previously found that the MTD of 1,25(OH)(2) D(3) is 0.0625 μg/mouse; therefore, inecalcitol is 480 times less hypercalcemic than 1,25OH2 D3[1]. Inecalcitol inhibits androgen-responsive prostate cancer growth in vivo.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 55 mg/ml (137.3 mM)
关键字: anticancer | antiproliferative | Vitamin D | ETV1 | Pim-1 | Vitamin D receptor | Apoptosis | VDR | Inecalcitol | VD/VDR | Inhibitor | inhibit
相关产品: Picropodophyllin | Ceranib-2 | Sodium salicylate | Bisindolylmaleimide VIII acetate | KW-2449 | AT9283 | Pinosylvin | Antitumor agent-103 | Angiotensin II human | SC66
相关库: Apoptosis Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途