化合物GlyH-101 T2451

Product Introduction
Bioactivity


英文名: GlyH-101

描述: GlyH-101 是一种可渗透入细胞的 CFTR 阻断剂，Ki 为1.4 uM。

体外活性: GlyH-101 在不到1分钟内可逆地抑制CFTR Cl- 通道的传导。[1] 在分离的兔心室肌细胞中，GlyH-101 还阻断心脏I(Cl.PKA) 通道。[2] 在转染的FRT (SLC26A9-FRT) 细胞中，GlyH-101 抑制由SLC26A9介导的Cl- 电流。[3]

体内活性: In mice, Topical GlyH-101 (10 μM) in mice rapidly and reversibly inhibits forskolin-induced hyperpolarization in nasal potential differences. In a cholera model, intraluminal GlyH-101 (2.5 μg) reduces cholera toxin-induced intestinal fluid secretion by approximately 80%.[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 49.3 mg/mL (100 mM)


关键字: Inhibitor | antiproliferative | PCT | inhibit | PS120 cells | GlyH-101 | GlyH101 | intestinal fluid | VSORC | CFTR-like current | Cystic fibrosis transmembrane conductance regulator | CFTR

相关产品: WAY-326766 | PPQ-102 | CFTR corrector 9 | VRT-532 | Glibenclamide | CFTR corrector 4 | Bamocaftor | Ataluren | Cavosonstat | CFTR corrector 12

相关库: Ion Channel Inhibitor Library | ReFRAME Related Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Fibrosis Compound Library | Autophagy Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途