化合物NP-313 T24542

Product Introduction
Bioactivity


英文名: NP-313

描述: NP-313 (NSC-4264) 是一种有效的抗血栓剂，对血栓素 A 2 合成和选择性抑制由 SOCC 介导的 Ca 2+ 内流有抑制作用，可以抑制血小板的聚集和活化。

体外活性: NP-313 (0-80 μM) can inhibit platelet aggregation in a dose-dependent manner. Among them, NP-313 can inhibit thrombin- and A23187-induced platelet aggregation to a maximum extent of about 80% and 60%, respectively.[1] NP-313 (0-8 μM) concentration-dependently inhibits P-selectin expression and collagen- or thrombin-induced thromboxane B 2 (TXB2) production in human platelets. Meanwhile, NP-313 inhibits COX-1 and TXA 2 synthase with IC50 values of 1.5 and 3.9 µM, respectively.[1]

体内活性: NP-313 (4-16 µg/g; i.v.) significantly prolongs time-to-occlusion (TTO), prolongs bleeding time, and inhibits platelet aggregation induced by collagen (10 µg/mL) in male ICR mice.[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 60 mg/mL (240.34 mM)


关键字: NP-313 | NP313

相关库: Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途