化合物ZINC69391 T24833

Product Introduction
Bioactivity


英文名: ZINC69391

描述: ZINC69391 (CysHHC10 acetate(1408311-03-4 free base)) 是 Rac1 的选择性抑制剂，具有抗增殖和抗转移作用。 ZINC69391 干扰 Rac1 与 Dock180 的相互作用，降低 Rac1-GTP 水平并诱导细胞凋亡。

体外活性: In U-87 MG and LN229 cells, ZINC69391 (0-125 μM) reduces cell proliferation of human glioma cells. ZINC69391 (50-100 μM) triggers cell cycle arrest[1]. ZINC69391 inhibits the growth of U937, HL-60, KG1A, and Jurkat cells (IC50s = 41-54 μM). In HL-60, U937, and KG1A cell lines, ZINC69391 (50 μM) triggers an increase in apoptotic cells. In LN229 cells, ZINC69391 (50 and 100 μM) augments the enzymatic activity of caspase 3 and increases the percentage of cells in the sub-G0/G1 phase in a concentration-dependent manner[3].

体内活性: In specific pathogen-free female BALB/c inbred mice (bearing F3II cells), ZINC69391 (25 mg/kg; i.p) impairs metastatic lung colonization and reduces by about 60% the formation of total metastatic lung colonies[2].

存储条件: store at low temperature,keep away from direct sunlight,keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 20 mg/mL (64.66 mM)


关键字: ZINC69391

相关产品: 1,4-Dideoxy-1,4-epithio-D-ribitol | Bigelovin | SMIP004 | Takinib | Alvespimycin hydrochloride | HFY-4A | Dihydrorotenone | L-Ascorbic acid sodium salt | BIBR 1532 | EGFR-IN-3

相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Cytoskeletal Signaling Pathway Compound Library | PPI Inhibitor Library | Bioactive Compound Library

化合物ZINC69391 T24833信息由TargetMol中国为您提供，如您想了解更多关于化合物ZINC69391 T24833报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途