化合物BAY 87-2243 T2488

Product Introduction
Bioactivity


英文名: BAY 87-2243

描述: BAY 87-2243 是一种选择性的低氧诱导因子-1 抑制剂。

细胞实验: To evaluate the cytotoxicity of BAY 87-2243, 2.000 cells of the respective cell lines are seeded in 96-well plates and cultured in the appropriate growth medium containing 10% FCS. BAY 87-2243 at various concentrations is added at 24 h after seeding for additional 48 h and cell viability is determined using Cell Titer Glow Assay.(Only for Reference)

体外活性: BAY87-2243（4 mg/kg口服）减少H460异种移植小鼠模型中肿瘤重量,HIF-1α蛋白和HIF-1靶基因表达水平.

体内活性: 在缺氧肺癌H460细胞中,BAY 87-2243抑制HIF靶基因表达,并抑制HIF-1α蛋白质积累。BAY 87-2243在葡萄糖消耗下,通过干扰线粒体功能抑制细胞增殖。BAY87-2243抑制HIF-1的报告基因活性和CA9蛋白表达,IC50分别为0.7 nM 和2 nM。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 5.25 mg/mL (10 mM)


关键字: Ferroptosis | inhibit | BAY 87-2243 | HIFs | HIF-PH | HIF/HIF Prolyl-Hydroxylase | Inhibitor | BAY 872243 | Hypoxia-inducible factors | BAY 87 2243

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相关库: Drug Repurposing Compound Library | Glycometabolism Compound Library | Transcription Factor-Targeted Compound Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Fluorochemical Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Active Compound Library | Anti-Pancreatic Cancer Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途