卡奈替尼二盐酸盐 T2501
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mL | 289499-45-2 | ¥497.00 | 询底价 |
50 mg | 289499-45-2 | ¥698.00 | 询底价 |
100 mg | 289499-45-2 | ¥996.00 | 询底价 |
10 mg | 289499-45-2 | ¥457.00 | 询底价 |
200 mg | 289499-45-2 | ¥1,762.00 | 询底价 |
500 mg | 289499-45-2 | ¥3,997.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Canertinib dihydrochloride
描述: Canertinib dihydrochloride (PD-183805 dihydrochloride) 是一种可口服的喹唑啉盐酸盐,具有潜在的抗肿瘤和放射增敏活性,抑制细胞 EGFR 和 ErbB2自身磷酸化的 IC50值分别为 7.4 和 9 nM。
激酶实验: Kinase inhibition: Cediranib is dissolved in DMSO at a concentration of 10 mM. All enzyme assays are run at, or just below, the respective Km for ATP (0.2 - 30 μM). The inhibitory activity of Cediranib is determined against a range of recombinant tyrosine kinases [KDR, Flt-1, Flt-4, c-Kit, PDGFRα, PDGFRβ, CSF-1R, Flt-3, FGFR1, Src, Abl, epidermal growth factor receptor (EGFR), ErbB2, Aurora A, and Aurora B] using ELISA. Selectivity versus CDK2 and CDK4 serine/threonine kinases is examined using scintillation proximity assays with a retinoblastoma substrate and [γ-sup>33P]ATP. Activity of Cediranib is compared to MAPK kinase (MEK), which shows dual specificity. It is determined using a MAPK substrate, [γ-33P]ATP, and paper capture/scintillation counting.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 55.9 mg/mL(100 mM)
关键字: ErbB-1 | PD 183805 | PD 183805 Dihydrochloride | Orthopoxvirus | PD-183805 | EGFR | Canertinib dihydrochloride | CI 1033 Dihydrochloride | PD183805 Dihydrochloride | PD183805 | CI1033 Dihydrochloride | Epidermal growth factor receptor | CI 1033 | PD-183805 Dihydrochloride | Inhibitor | CI1033 | inhibit | HER1 | CI-1033 | Canertinib Dihydrochloride | CI-1033 Dihydrochloride
相关产品: FIIN-3 | Khellin | EGFR-IN-99 | Ligustroside | Tyrphostin 23 | JGK-068S | PD158780 | (S)-Sunvozertinib | Oligopeptide-41 | Mobocertinib
相关库: Drug Repurposing Compound Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Inhibitor Library | Tyrosine Kinase Inhibitor Library | Anti-Cancer Active Compound Library | Reprogramming Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途