环索奈德 T2526

Product Introduction
Bioactivity


英文名: Ciclesonide

描述: Ciclesonide (Alvesco) 是一种糖皮质激素，具有强效抗炎活性，可用于研究哮喘。

细胞实验: Metabolism of ciclesonide: After initial cultivation, A549 cells are washed five times with 10 ml/dish sterile PBS. An ethanolic stock solution of ciclesonide is diluted 1000-fold with assay medium to generate the initial ciclesonide concentration. The cells are incubated for 1 h in DMEM/0.1% (w/v) BSA (5 ml/dish) containing 0.02 μM ciclesonide as described above in a CO2 incubator. At the end of the incubation period, dishes are washed five times with PBS and incubated for 3, 6, or 24 h at the same conditions in 5 ml/dish fresh medium (DMEM/0.1% (w/v) BSA). At each indicated time point, the medium is removed by aspiration, 5 mM EDTA-4Na/PBS added and dishes are incubated for further 5 min. The cells are detached from the dishes and harvested. Each dish is washed five times with icechilled PBS. (Only for Reference)

体外活性: Ciclesonide is effectively taken up into human alveolar type II epithelial (A549) cells and metabolized to its pharmacologically active metabolite des-CIC and fatty acid conjugates of desCIC[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 54.1 mg/mL (100 mM)
DMSO : 54.1 mg/mL (100 mM)


关键字: Inhibitor | RPR 251526 | Ciclesonide | RPR-251526 | inhibit | Glucocorticoid Receptor

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相关库: Anti-COVID-19 Compound Library | Approved Drug Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Anti-Cancer Clinical Compound Library | Pediatric Drug Library | Anti-Cancer Approved Drug Library | Endocrinology-Hormone Compound Library | Orally Active Compound Library | NO PAINS Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途