拉坦前列素 T2528

Product Introduction
Bioactivity


英文名: Latanoprost

描述: Latanoprost (Xalatan) 是前列腺素 F2α 类似物，是一种前列腺素受体激动剂，能够降低眼内压。

细胞实验: HCS cells were inoculated into a 24-well culture plate (Nunc) and cultured in 10% FBS-DMEM/F12 medium at 37°C in a humidified 5% CO2 incubator. After the cells grew into logarithmic phase, the culture medium of each culture plate well was replaced entirely with the medium containing latanoprost at concentrations varying from 50 mg/l to 0.78125 mg/l, respectively. The cells were cultured under the same condition as described earlier, and their morphology and growth status were monitored every 4 h under an Eclipse TS100 inverted microscope.(Only for Reference)

体外活性: Latanoprost functioned as both an indirect activator of AMP-activated protein kinase and a selective retinoid X receptor α (RXRα) antagonist able to selectively antagonise the transcription of a RXRα/peroxisome proliferator-activated receptor γ heterodimer[2]. Latanoprost induced morphological abnormality and viability decline of HCS cells in vitro. It induces cell cycle arrest of HCS cells. Latanoprost induces abnormal changes of plasma membrane, DNA fragmentation and ultrastructural abnormality of HCS cells. Caspase activation in HCS cells is also activated by Latanoprost treatment. Latanoprost induces MTP disruption and quantitative changes of mitochondrion-associated pro-apoptotic regulators in HCS cells[1]. Latanoprost is effective in inhibiting adipogenesis, reducing lipogenesis, promoting fatty acid oxidation and enhancing GLUT4 translocation and glucose uptake both in adipocytes and myotubes[2].

体内活性: Latanoprost, a clinical drug for treating primary open-angle glaucoma and intraocular hypertension, effectively ameliorates glucose and lipid disorders in two mouse models of type 2 diabetes. Its treatment improves glucose tolerance. Chronic administration of latanoprost decreases serum lipids and enhances insulin signalling in white adipose tissue and skeletal muscle. It effectually activates AMPK and regulates glucose and lipid metabolism-relevant genes in diabetic mice[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 4.33 mg/mL (10 mM)


关键字: PHXA 41 | Inhibitor | Prostaglandin Receptor | Latanoprost | PHXA-41 | inhibit

相关产品: CRTh2 antagonist 2 | (1S,2R)-2-PCCA | Kisspeptin-10, human (TFA)(374675-21-5,FREE) | Tetrahydromagnolol | AM-4668 | TUG-1375 | LP-471756 | Firuglipel | MS21570 | Fezagepras

相关库: Drug Repurposing Compound Library | Approved Drug Library | Anti-COVID-19 Compound Library | Anti-Cancer Drug Library | Clinical Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Approved Drug Library

拉坦前列素 T2528信息由TargetMol中国为您提供，如您想了解更多关于拉坦前列素 T2528报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途