癸酸诺龙 T2556
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
200 mg | 360-70-3 | ¥2,200.00 | 询底价 |
100 mg | 360-70-3 | ¥1,460.00 | 询底价 |
1 mL | 360-70-3 | ¥278.00 | 询底价 |
5 mg | 360-70-3 | ¥287.00 | 询底价 |
50 mg | 360-70-3 | ¥981.00 | 询底价 |
25 mg | 360-70-3 | ¥665.00 | 询底价 |
500 mg | 360-70-3 | ¥3,550.00 | 询底价 |
10 mg | 360-70-3 | ¥407.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Nandrolone decanoate
描述: Nandrolone decanoate (19-Nortestosterone decanoate) 是一种合成代谢雄激素,通过涉及谷氨酸诱导的 N-甲基-D-天冬氨酸受体过度兴奋的机制诱导攻击性行为表征。
细胞实验: Cell viability is assessed one, three and five days after incubation with nandrolone decanoate at the final concentrations of 5, 10, 25 and 50 µM or the drug vehicle (1.5:1-benzyl alcohol/peanut oil), added in different amounts according to the anabolic concentrations (vehicle 5, 10, 25 and 50 µM, respectively). Together with the treatment with the anabolic steroids, 2% horse serum was added to the culture for the induction of differentiation of muscle cells. (Only for Reference)
激酶实验: Affinity assay: The affinity of Aclidinium for the different human muscarinic receptor subtypes at equilibrium is determined by measuring their ability to displace the binding of [3H]NMS to cell membrane preparations expressing one of the human muscarinic receptor subtypes. Protein concentrations are 8.1 μg/well, 10.0 μg/well, 4.9 μg/well, 4.5 μg/well, and 5.0 μg/well for M1, M2, M3, M4, and M5 receptor membrane preparations, respectively. The assays are conducted at [3H]NMS concentrations approximately equal to the radioligand equilibrium dissociation constant (Kd) for the different muscarinic receptors subtypes. The [3H]NMS concentration is 0.3 nM for the M1 and M4 assays and 1 nM for the M2, M3, and M5 assays. A range of antagonist concentrations (10?14 to 10?5 M) are tested in duplicate to generate competition curves. Nonspecific binding is determined in the presence of atropine (1 μM). Assay reagents are dissolved in assay binding buffer (phosphate-buffered saline with calcium and magnesium) to a total volume of 200 μL. After a 2 hours or 6 hours incubation period (M1–M4 and M5, respectively) at room temperature in 96-well microtiter plates to ensure that equilibrium is achieved for Aclidinium, 150 μL aliquots of the reaction are transferred to GF/C filter plates pretreated for 1 hour with wash buffer (50 mM Tris, 100 mM NaCl, pH 7.4) containing 0.05% polyethylenimine. Bound and free [3H]NMS are then separated by rapid vacuum filtration followed by four washes with ice-cold wash buffer. Filters are then dried for 30 min before addition of 30 μL of OptiPhase Supermix, and radioactivity is quantified using a MicroBeta Trilux microplate scintillation counter.
体外活性: The anabolic steroid nandrolone decanoate with the used concentrations, is not able to change the viability of muscle cells during the in vitro differentiation process[2].
体内活性: High nandrolone decanoate doses lead to decreased serum glucose, accompanied by high serum insulin levels during fasting. Glucose production rate and liver glycogen content are decreased by the chronic administration of nandrolone decanoate, probably resulting in decreased fasting glucose[1]. In vivo studies demonstrate that the effects of nandrolone decanoate depended on the assessed muscles, time of treatment, dose and association or not with exercises. All of these are able to cause increased muscle mass, alterations in the cell cycle, bone mineral density, bone growth, and the ARs influence these effects[2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 4.29 mg/mL (10 mM)
关键字: inhibit | NMDAr | HIV | Human immunodeficiency virus | behavior | Inhibitor | glutamate | aggressive | Androgen Receptor | GLT-1 | memantine | transporter | Nandrolone decanoate
相关产品: 1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one | Nelfinavir | (2RS)-FPMPA | lithospermic acid | Salaspermic acid | ONX-0914 | Mk-6186 HCl | Rosamultin | 8-Prenylluteone | 6'-O-Galloylsalidroside
相关库: FDA-Approved Drug Library | Drug Repurposing Compound Library | Anti-COVID-19 Compound Library | Approved Drug Library | Bioactive Compounds Library Max | Pediatric Drug Library | Endocrinology-Hormone Compound Library | NO PAINS Compound Library | Anti-Infection Compound Library | Bioactive Compound Library
癸酸诺龙 T2556信息由TargetMol中国为您提供,如您想了解更多关于癸酸诺龙 T2556报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途