克拉屈滨 T2558
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mL | 4291-63-8 | ¥327.00 | 询底价 |
100 mg | 4291-63-8 | ¥1,692.00 | 询底价 |
10 mg | 4291-63-8 | ¥289.00 | 询底价 |
50 mg | 4291-63-8 | ¥996.00 | 询底价 |
200 mg | 4291-63-8 | ¥2,538.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Cladribine
描述: Cladribine (2CdA) 是一种嘌呤核苷类似物,是具有口服活性的腺苷脱氨酶抑制剂。它能作为 DNA 合成的抑制剂,可阻断受损 DNA 的修复。它可抑制 DNA 甲基化,具有抗淋巴瘤活性,可研究血液恶性肿瘤和多发性硬化。
细胞实验: The non-radioactive cell proliferation kit is used to determine cell viability. In brief, Human MM cell line U266, RPMI8226 and MM1.S are seeded onto 96-well plates with either 0.1 mL complete medium (5% FBS) as control, or 0.1 mL of the same medium containing a series of doses of cladribine, and incubated for 72 hours. After reading all wells at 490 nm with a micro-plate reader, the percentages of surviving cells from each group relative to controls, defined as 100% survival, are determined by reduction of MTS.(Only for Reference)
体外活性: 在成年斑马鱼中,腹腔注射Cladribine(0.7-3.5 mM ),能够抑制RBC ATP浓度水平.
体内活性: 在原代肥大细胞(MC)和MC系HMC-1中,Cladribine抑制细胞生长。在CD14 +单核细胞以及CD4 +和CD8 + T淋巴细胞中,Cladribine降低细胞迁移能力。在U266,RPMI8226和MM1.S细胞中,Cladribine以剂量依赖性方式抑制细胞增殖。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: Ethanol : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 53 mg/mL (185.5 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
关键字: HCL | multiple | Adenosine Deaminase | leukemia | lymphoma | follicular | MALT | cell | MCL | DLBCL | chronic | Inhibitor | hairy | mucosa-associated | tissue | mantle | lymphoid | sclerosis | CLL | Apoptosis | Cladribine | lymphocytic | inhibit
相关产品: (20S)-Protopanaxatriol | Ethyl pyruvate | Dacarbazine | Telomerase-IN-4 | (+)-δ-Cadinene | Mitoguazone | Ac-IETD-CHO | Bcl-B inhibitor 1 | Capmatinib | RGD peptide (GRGDNP)
相关库: Anti-Neurodegenerative Disease Compound Library | Drug Repurposing Compound Library | Approved Drug Library | Toxic Compound Library | Anti-Cancer Drug Library | Anti-Cancer Clinical Compound Library | Inhibitor Library | Anti-Cancer Active Compound Library | Anti-Cancer Approved Drug Library | EMA Approved Drug Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途