化合物Lecimibide T25651

Product Introduction
Bioactivity


英文名: Lecimibide

描述: Lecimibide (DuP 128) 是一种有效且具有选择性的酰辅酶 A 胆固醇酰基转移酶(ACAT)抑制剂，可用于研究由于高脂带来的疾病。

体外活性: Lecimibide (DuP 128) (10 μM; 24 h) can inhibit 85% of the cellular esterification reaction in HepG2 cells.[1]

体内活性: Lecimibide (DuP 128) (2.2 mg/kg/day.; i.v) significantly reduced total plasma triglyceride and very low-density lipoprotein (VLDL) triglyceride concentrations in pigs fed high fat and cholesterol, respectively 36% and 31%. There were no significant effects on total cholesterol, VLDL cholesterol, LDL cholesterol, HDL cholesterol, or LDL apo B concentrations.[2]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 55 mg/mL (93.1 mM)


关键字: Lecimibide

相关产品: YM-750 | Xanthohumol | 24-Methylenecholesterol | BAY-3827 | Avasimibe | YM17E | PD 128042 | BMS-986172 | PF-07202954 | PF-06424439

相关库: Bioactive Compounds Library Max | Inhibitor Library | Bioactive Compound Library

化合物Lecimibide T25651信息由TargetMol中国为您提供，如您想了解更多关于化合物Lecimibide T25651报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途