贝达喹啉 T2585

Product Introduction
Bioactivity


英文名: Bedaquiline

描述: Bedaquiline (R207910) 是一种二芳基喹啉药物，能同时靶向 c-亚基和 ε-亚基，抑制结核分枝杆菌 (Mtb) F1FO-ATP 合酶。它具有解偶联活性和有用于耐多药结核病的潜力。

体外活性: Bedaquiline inhibits the growth of TDR M. tuberculosis strains, with MIC values ranging from 0.125 to 0.5 mg/L[1]. Among slowly growing mycobacteria (SGM), bedaquiline exhibits the highest activity against Mycobacterium avium with MIC50 and MIC90 values of 0.03 and 16 mg/L, respectively. Among rapidly growing mycobacteria (RGM), Mycobacterium abscessus subsp. abscessus (M. abscessus) and Mycobacterium abscessus subsp. massiliense (M. massiliense) seem more susceptible to bedaquiline than Mycobacterium fortuitum, with MIC50 and MIC90 values of 0.13 and >16 mg/L, respectively, for both species. Bedaquiline also shows moderate in vitro activity against NTM species[2]. Bedaquiline has an excellent in vitro activity against Mycobacterium tuberculosis, including multidrug resistant M tuberculosis[3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 5.56 mg/mL (10 mM)


关键字: TMC 207 | Bacterial | Antibiotic | TMC-207 | Bedaquiline | R 207910 | R-207910 | Inhibitor | inhibit

相关产品: Sulfaquinoxaline | Pentamidine isethionate | Continentalic acid | Indolicidin | Enmetazobactam | Dapsone | Ripasudil free base | WR99210 | Isovalerylshikonin | (+)-Viroallosecurinine

相关库: FDA-Approved Drug Library | Drug Repurposing Compound Library | Approved Drug Library | Antibiotics Library | Bioactive Compounds Library Max | Ferroptosis Compound Library | Inhibitor Library | Highly Selective Inhibitor Library | EMA Approved Drug Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途