依氟鸟氨酸盐酸盐一水合物 T2593

Product Introduction
Bioactivity


英文名: Eflornithine hydrochloride hydrate

描述: Eflornithine hydrochloride hydrate (RMI-71782 hydrochloride hydrate) 是一种特异性的、不可逆的酶鸟氨酸脱羧酶抑制剂。它可用于研究非洲锥虫病和女性面部毛发过度生长。

细胞实验: BY2 cells are treated with or without cryptogein in the presence or absence of DFMO(Difluoromethylornithine) and monitered the effect of chemicals on cell growth. (Only for Reference)

体外活性: When cultured cells are treated with α-difluoromethyl-Orn, an inhibitor of polyamine biosynthesis, production of hydrogen peroxide is suppressed and programmed cell death did not occur[1].

体内活性: Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases[2]. Eflornithine 15% cream is superior to a placebo in reducing hair growth in subjects with excessive, unwanted facial hair. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism[3]. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles[4]. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension[5].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 55 mg/mL (232.42 mM)


关键字: inhibit | DFMO hydrochloride | α-difluoromethylornithine hydrochloride | α-difluoromethylornithine hydrochloride Hydrate | RMI-71782 hydrochloride Hydrate | Eflornithine hydrochloride Hydrate | Eflornithine Hydrochloride | Eflornithine hydrochloride hydrate | MDL-71782 hydrochloride Hydrate | Inhibitor | a-difluoromethylornithine hydrochloride Hydrate | Difluoromethylornithine hydrochloride Hydrate | MDL-71782 hydrochloride | RMI-71782 hydrochloride | Parasite | DFMO hydrochloride Hydrate

相关产品: Tritoqualine | L-Ornithine | α-Hydroxyglutaric Acid Lithium | Carbidopa | Carbidopa monohydrate | 4-Bromo-3-hydroxybenzoic acid

相关库: Drug Repurposing Compound Library | Anti-COVID-19 Compound Library | FDA-Approved & Pharmacopeia Drug Library | Clinical Compound Library | Inhibitor Library | Pediatric Drug Library | Highly Selective Inhibitor Library | Anti-Parasitic Compound Library | Metabolism Compound Library | NO PAINS Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途