罗贝考昔 T26109

Product Introduction
Bioactivity


英文名: Robenacoxib

描述: Robenacoxib (Onsior) 是一种对环氧化酶-2 有很强的选择性的非甾体化合物，具有抗炎活性。

体内活性: Robenacoxib (2 mg/kg; oral; dogs) by oral (tablet) administration was effective and well tolerated in the control of peri-operative pain and inflammation associated with soft tissue surgery in dogs. Significantly (P = 0.019) more dogs administered Robenacoxib were considered treatment successes (89 of 116, 76.72%) compared to dogs given a placebo (74 of 115, 64.35%). The percentage of treatment failure was therefore 23.28% in the Robenacoxib and 35.65% in the placebo group. The least squares mean total pain scores were significantly different between groups and in favor of Robenacoxib at 3 and 5 hours (P < 0.05) and 8 hours post-extubation (P < 0.01). Pain at the surgery sites (response to touch) was also significantly improved at 3, 5, and 8 hours post-extubation in dogs receiving Robenacoxib versus placebo (P < 0.01). In addition, a significant overall improvement in posture/activity was revealed with Robenacoxib having lower scores versus placebo (P < 0.01). No significant differences between the Robenacoxib and placebo groups in the frequency of reported adverse events were observed.[2]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 45 mg/mL (137.5 mM)


关键字: Robenacoxib

相关产品: 6-Acetamidohexanoic acid | Esculentoside A | Timegadine | Fenoprofen calcium hydrate | S-(+)-Ketoprofen | Phenidone | (-)-Catechin gallate | Tetrahydroamentoflavone | Isoxicam | Thioflosulide

相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途