6-羟基-DL-多巴 T26396

Product Introduction
Bioactivity


英文名: 6-Hydroxy-DOPA

描述: 6-Hydroxy-DOPA 是 RAD52 的变构抑制剂，可用于癌症研究。它在体外抑制 BRCA 缺陷癌细胞的增殖，也抑制 APE1。

体外活性: We identify the small molecule 6-hydroxy-DL-dopa (6-OH-dopa) as a major allosteric inhibitor of the RAD52 ssDNA binding domain. For example, we find that multiple small molecules bind to and completely transform RAD52 undecamer rings into dimers, which abolishes the ssDNA binding channel observed in crystal structures. 6-OH-Dopa also disrupts RAD52 heptamer and undecamer ring superstructures, and suppresses RAD52 recruitment and recombination activity in cells with negligible effects on other double-strand break repair pathways.

体内活性: Importantly, we show that 6-OH-dopa selectively inhibits the proliferation of BRCA-deficient cancer cells, including those obtained from leukemia patients. Taken together, these data demonstrate small-molecule disruption of RAD52 rings as a promising mechanism for precision medicine in BRCA-deficient cancers.

存储条件: store at low temperature,keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 2.13 mg/mL (10 mM)


关键字: U20S | DNA/RNA Synthesis | effective | ssDNA | 6 Hydroxy DOPA | 6HydroxyDOPA | Inhibitor | allosteric | inhibit | selective | HCC1937 | 6-Hydroxy-DOPA | cancer

相关产品: IBR2 | Daptomycin | 360A | Rimantadine hydrochloride | APE1-IN-1 | IDD388 | RAD51-IN-1 | DTP3 | Communic acid | TH287 hydrochloride

相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Active Compound Library | DNA Damage & Repair Compound Library | Bioactive Compound Library

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