联苯三唑醇 T26829

Product Introduction
Bioactivity


英文名: Bitertanol

描述: Bitertanol (KWG 0599) 是一种三唑类杀菌剂。 Bitertanol 抑制去甲基化，破坏膜功能，并阻止甾醇合成。

体内活性: Bitertanol (10, 25, and 100 mg/kg) produced 2-, 4-, and 14-fold increases of 7-ethoxyresorufin O-deethylation activity in liver microsomes, respectively. Bitertanol (25 mg/kg) increased CYP1A1 protein in the liver, kidney, and lung by 10-, 13-, and 17-fold, respectively. Bitertanol produced smaller increases of CYP2B and CYP3A catalytic activity and protein than that of CYP1A1 in liver. Additions of 0.01-100 microM Bitertanol to liver microsomes from rats Bitertanol (25 mg/kg) inhibited microsomal 7-ethoxyresorufin O-demethylation activity (IC50=0.8 microM). Bitertanol (100 mg/kg) increased liver UDP-glucuronosyltransferase and glutathione S-transferase activities by 2-fold. Bitertanol (25 mg/kg) produced a minor increase in metabolic activation of benzo[a]pyrene by liver S-9 fraction in the Ames mutagenicity test while the increase was blocked by addition of 100 microM Bitertanol[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 12 mg/mL (35.56 mM)


关键字: Bitertanol

相关产品: (-)-Isocorypalmine | Cratoxylone | Demethoxyencecalin | Santalol | Isavuconazole | Oligomycin A | Cerulenin | Myclobutanil | Triclosan | (+)-Magnoflorine

相关库: Bioactive Compounds Library Max | Inhibitor Library | Bioactive Compound Library

联苯三唑醇 T26829信息由TargetMol中国为您提供，如您想了解更多关于联苯三唑醇 T26829报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途