化合物LY310762 T2688

Product Introduction
Bioactivity


英文名: LY310762

描述: LY310762 是 5-HT1D 受体拮抗剂，Ki 为 249 nM。

体外活性: LY310762处理后,氟西汀处理的动物体内5-HT的水平从312±43%增加到最大水平683%.在对照组动物中,5-HT的水平保持250%不变.与接受对照载体注射的动物相比,全身给药10 mg/kg i.p. LY310762更明显地增强5-HT对20 mg/kg i.p. 氟西汀的响应.LY310762单独给药使5-HT的基础水平明显增加到高于载体对照,与预注射的对照组相比,能够达到最大值258%.

体内活性: LY310762增强来自豚鼠皮质切片的钾诱导的[3H] 5-HT流出,EC50为30 nM。LY310762对钾诱导[3H]5-HT流出的最大增强作用大约为40%。LY310762对豚鼠5-HT1D受体的亲和力高于对5-HT1B受体的亲和力。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 43.1 mg/mL (100 mM)
H2O : 4.3 mg/mL (10 mM)


关键字: 5-HT Receptor | LY-310762 | 5-hydroxytryptamine Receptor | Inhibitor | LY310762 | Serotonin Receptor | inhibit | LY 310762

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途