醋酸棉酚 T2730

Product Introduction
Bioactivity


英文名: Gossypol (acetic acid)

描述: Gossypol acetic acid (AT101) 是一种从棉籽中分离出来的多酚天然产物，分别与 Bcl-xL 蛋白和 Bcl-2蛋白结合，Ki 值分别为 0.5-0.6 μM 和 0.2-0.3 mM。

细胞实验: MM(Multiple myeloma) cells are plated in 24-cell culture clusters at a density of 1x105 viable cells/l per well. Triplicate wells are treated with 1, 5, 10, 25 and 50 µmol/l gossypol acetate, and the negative control group is supplemented with 0.1% DMSO. Then, cell numbers at different treatment time points (0, 24, 48 and 72 h) are determined by using a hemocytometer and the trypan blue dye-exclusion method. The trypan blue dye-exclusion method is used to evaluate the cell viability. The cells are examined in a counting chamber under a light microscope. Only viable cells are recorded. (Only for Reference)

体外活性: Gossypol, a known antispermatogenic agent from the cotton plant genus Gossypium, was found to inhibit yellow perch sperm motility in vitro and lactate dehydrogenase activity in spermatozoa when used in a dose-dependent manner[1]. Gossypol has been approved to have antiproliferative and apoptosis-inducing effects on some kinds of cancer cell lines in vitro[2].

体内活性: Gossypol acetate is able to inhibit tumor growth in Wus1-bearing mice, but the survival of mice is not prolonged, and tumor grows rapidly after short inhibition. Gossypol has now been found to have inhibitory effects on proliferation or to induce apoptosis in ovarian cancer, endometrial cancer, adrenal cortical tumor, thyroid cancer, lung cancer, colon carcinoma, leukemia, pancreatic cancer, melanoma and lymphoma. In addition, gossypol can increase the sensitivity of drug-resistant tumor cells to chemotherapy and radiotherapy. Some Clinicalal trials showed gossypol is well-tolerated, and partial responses are observed in some patients[4].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 100 mg/mL (172.82 mM)
Ethanol : 2 mg/mL(3.5 mM)


关键字: acetic acid | inhibit | Gossypol-acetic acid | AT 101 | Inhibitor | AT-101 | Gossypol | BL-193 (acetic acid) | Gossypol (acetic acid) | Bcl-2 Family

相关产品: Jaceosidin | Dehydrocavidine | Bax activator-1 | Ciwujianoside B | Panaxynol | Desmorpholinyl Navitoclax-NH-Me | Epieriocalyxin A | Bcl-B inhibitor 1 | MIM1 | Diphenyl disulfide

相关库: Polyphenolic Natural Product Library | Selected Plant-Sourced Compound Library | Covalent Natural Product Library

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