Fasnall盐酸盐 T27307L

Product Introduction
Bioactivity


英文名: Fasnall HCl

描述: Fasnall HCl 是一种FASN 选择性抑制剂，通过其辅助因子结合位点起作用。Fasnall HCl 在HER2(+)乳腺癌MMTV-Neu 模型中也显示出强大的抗肿瘤活性，特别是与卡铂联合使用时。

体外活性: Fasnall HCl potently blocked both acetate and glucose incorporation into total lipids, with IC50 values of 147 and 213 nM, respectively, in HepG2 cells. Fasnall HCl inhibited FASN with IC50 values of 3.71 μM in vitro. The molecules were tested in the acetate incorporation assay in BT474 cells. Fasnall HCl is able to inhibit the incorporation of tritiated acetate (IC50 5.84 μM, respectively) into lipids [1].

体内活性: FVB/J mice received 5, 20, or 80 mg/kg Fasnall HCl via intraperitoneal injection on days 1 and 3. Fasnall HCl was toxic at 80 mg/kg, but at 5–20 mg/kg was well tolerated with no adverse effects on white blood cell counts, hemoglobin levels, kidney, or liver functions. Cohorts of MMTV-Neu mice were treated with a biweekly intraperitoneal injection of 15 mg/kg Fasnall HCl, shows that Fasnall HCl reduced tumor volume compared with vehicle-treated animals [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 22.5 mg/mL (60.01 mM)


关键字: Fasnall HCl | 929978-58-5 Free base | 929978-58-5

相关产品: FASN-IN-3 | L-Carnitine | Orlistat | Fatostatin | Pyrazinamide | Gallocatechin gallate | Hydroxycitric acid | UCM05 | Isoscoparin | Icariside E4

相关库: Anti-Cancer Metabolism Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Obesity Compound Library | Anti-Cancer Active Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途