非地沙班 T27318
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 mg | 183305-24-0 | ¥8,270.00 | 询底价 |
5 mg | 183305-24-0 | ¥2,520.00 | 询底价 |
1 mg | 183305-24-0 | ¥990.00 | 询底价 |
10 mg | 183305-24-0 | ¥3,710.00 | 询底价 |
100 mg | 183305-24-0 | ¥10,900.00 | 询底价 |
25 mg | 183305-24-0 | ¥5,980.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Fidexaban
描述: Fidexaban (CI1031) 是一种新型、强效、选择性和口服活性 Xa 因子抑制剂,在多种测定中均显示出抗血栓活性。
体外活性: CI-1031 (ZK-807834) is a novel, synthetic factor Xa (FXa) inhibitor with a Ki of 0.11 nM against human FXa. In human plasma in vitro, CI-1031 doubled PT and aPTT at 0.23 and 0.49 microM, respectively. Ex vivo plasma anti-FXa activity was also well correlated with plasma concentration of CI-1031 and with PT (r = 0.96 and 0.98, respectively).[2]
体内活性: CI-1031 (ZK-807834) doubled PT and aPTT at 0.23 and 0.49 microM, respectively. The in vivo antithrombotic effect of CI-1031 was evaluated in a veno-venous shunt model of thrombosis in anesthetized rabbits. After thrombus formation was verified in the first shunts, rabbits received either vehicle or CI-1031 intravenously (bolus injection of 60, 240, or 480 microg/kg followed by an infusion of 2, 8, or 16 microg/kg/min for 140 min, respectively). The second shunts were inserted after 20 min of infusion of CI-1031 or vehicle. CI-1031 dose-dependently prolonged time to occlusion (TTO) in the second shunts (35 +/- 21, 62 +/- 24, and 120 +/- 0 min for the three dose groups, respectively, vs. 10 +/- 1 min for vehicle). Thrombus mass (TM) was reduced in a dose-dependent manner by CI-1031 (42 +/- 7, 27 +/- 6, and 18 +/- 4 mg vs. 50 +/- 4 mg for vehicle). Maximal TM reduction was 70% with an IC(50) of 0.6 microg/ml. Among all the coagulation parameters tested, PT had the best correlation with plasma CI- 1031 concentration (r = 0.97). These results indicate that CI-1031, which is currently undergoing clinical evaluation, is an effective antithrombotic compound with a favorable efficacy-to-bleeding ratio. In addition, CI-1031 concentration in plasma can be monitored using PT or anti-Xa assays, thereby providing reliable methods to ensure safe and accurate dose titration of CI-1031.[2]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : < 1mg/ml (insoluble)
关键字: PD200022 | PD 200022 | ZK807834 | Fidexaban | CI 1031 | ZK 807834 | BX 807834
相关产品: Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate | Fondaparinux sodium | RWJ-445167 | Edoxaban | Eribaxaban | Apixaban | Dechloro Rivaroxaban | Rivaroxaban-d4 | O-Desmethyl apixaban sulfate sodium | 4-Chlorophenylurea
相关库: Bioactive Compounds Library Max | Inhibitor Library | Bioactive Compound Library
非地沙班 T27318信息由TargetMol中国为您提供,如您想了解更多关于非地沙班 T27318报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途