化合物Inz-1 T27617

Product Introduction
Bioactivity


英文名: Inz-1

描述: Inz-1 是一种有效的真菌特异性线粒体细胞色素 bc1 抑制剂，对酵母和人类的 IC50 分别为 8.092 和 45.320 μM。 Inz-1 可逆转氟康唑或其他三唑类抗真菌药对致病性真菌白色念珠菌的耐药性。

体外活性: Inz-1 against Candida and HepG2 respiring growth with IC50 values of 1.655 uM and >32 μM, respectively. Inz-1 (0-16 μM; 24 hours) inhibits the growth of the model yeast S. cerevisiae (strain BY4741) and C. albicans (SC5314) in media containing glucose or glycerol as the sole carbon source, while only mildly slowing growth in glucose. Inz-1 (0-100 μM; 24 hours) shows inhibition of yeast cytochrome B enzymatic activity in a concentration -dependent manner in both wild-type and F90Y mutant mitochondria. It exhibits inhibition of cytochrome bc1 from both S. cerevisiae and C. albicans with IC50 value of 2.5 μM and 8.0 μM, respectively. Inz-1 (0-100 μM; 24 hours) inhibits proliferation under forced respiration conditions only at 32 μM and only mildly at that concentration[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 45 mg/mL (168.99 mM)


关键字: Inz 1 | Fungal | inhibit | yeast | Inz-1 | Fluconazole | antifungal | Candida albicans | drug-resistance | Cytochrome P450 | Inhibitor | cell | CYPs | Cytochrome Bc 1 | Inz1

相关产品: Clobetasol propionate | (-)-Vorozole | (-)-Sparteine | PF-4981517 | Chlorzoxazone | Chrysosplenetin | Diflubenzuron | Phloracetophenone | Mefentrifluconazole | Ambroxol

相关库: Mitochondria-Targeted Compound Library | Anti-Cancer Compound Library | Anti-Metabolism Disease Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Metabolism Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途