10-羟基喜树碱 T2764

Product Introduction
Bioactivity


英文名: (S)-10-Hydroxycamptothecin

描述: (S)-10-Hydroxycamptothecin (10-HCPT) 是一种从喜树中分离的 DNA 拓扑异构酶 I 抑制剂。它显著诱导细胞凋亡，可研究肝癌、胃癌、结肠癌和白血病。

细胞实验: Cells are exposed to various concentrations of 10-Hydroxycamptothecin for 72 hours. Cell growth is monitored by the standard MTT assay.(Only for Reference)

体外活性: 在CAM模型中,10-Hydroxycamptothecin（25 nM）以浓度依赖性方式抑制血管生成.在携带有Colo 205异种移植物小鼠中,每2天口服10-Hydroxycamptothecin（2.5-7.5 mg / kg）,能够显著抑制肿瘤细胞生长.

体内活性: 在BT-20细胞（IC50=34.3 nM）和MDA-231细胞（IC50=7.27 nM）中,(S)-10-Hydroxycamptothecin抑制细胞生长。在pBR322质粒DNA中（EC50=0.35 μM）, (S)-10-Hydroxycamptothecin有效诱导的人拓扑异构酶I介导的易解离复合物的形成。在人微血管内皮细胞（HMEC）中,(S)-10-Hydroxycamptothecin能够剂量依赖性的抑制细胞生长（IC50=0.31 μM）,显着抑制HMEC的迁移（IC50=0.63 μM）,抑制血管形成（IC50=0.96 μM）。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 20 mg/mL (54.89 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : < 1 mg/mL (insoluble or slightly soluble)


关键字: c-Myc | Bcl-2 | caspase-1/3r | p53 | Cell-cycle | antitumor | Bax | Apoptosis | (S)10Hydroxycamptothecin | arrest | PCNA | G2/M | Topoisomerase | (S) 10 Hydroxycamptothecin

相关产品: Y-27632 | Ezatiostat | FMAU | Camptothecin | 18α-Glycyrrhetinic acid | Columbianadin | NVP-TAE 684 | MGCD-265 analog | Bacopaside II | DAPT

相关库: Drug Repurposing Compound Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Inhibitor Library | Anti-Colorectal Cancer Compound Library | Anti-Cancer Approved Drug Library | Anti-Cancer Active Compound Library | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Natural Product Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途