新橙皮苷二氢查尔酮 T2767

Product Introduction
Bioactivity


英文名: Neohesperidin Dihydrochalcone

描述: Neohesperidin Dihydrochalcone (Neohesperidin DC) 是一种合成的糖苷查耳酮，可用作低热量人造甜味剂，添加到各种食品和饮料中。

细胞实验: WST-8 dye is used in the cell viability assay. HIT-T15 and HUVEC cells are grown and maintained in Dulbecco's modified Eagle's medium, supplemented with 10% fetal bovine calf serum. 1000 cells in each well are incubated with various concentrations of neohesperidin dihydrochalcone (50, 100, 500 μM, 1 mM) and other compounds. After treating HIT-T15 and HUVEC cells with 500 μM HOCl, WST-8 dye is added to each well, and the absorbance is detected at 420 nm with microplate reader[1].

体内活性: Neohesperidin dihydrochalcone administration causes a significant reduction in the activities of two useful markers of liver damage, AST and ALT. The relative levels of NF-κB, IL-6, IL-1β and TNF-α protein in the liver of PQ-treated mice are inhibited by neohesperidin dihydrochalcone[3]. The embryotoxicity/teratogenicity of neohesperidin dihydrochalcone is examined in Wistar Crl:(WI)WU BR rats. No adverse effects are observed at neohesperidin dihydrochalcone levels of up to 5% of the diet, the highest dose level tested, at which the rats consumed about 3.3 g/kg body weight/day[4].

存储条件: keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 100 mg/mL (163.24 mM)
DMSO : 50 mg/mL (81.62 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)


关键字: Neohesperidin Dihydrochalcone | Reactive Oxygen Species | Inhibitor | inhibit

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途