化合物K6PC-5 T27710
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 mg | 756875-51-1 | ¥3,480.00 | 询底价 |
1 mL | 756875-51-1 | ¥892.00 | 询底价 |
1 mg | 756875-51-1 | ¥347.00 | 询底价 |
10 mg | 756875-51-1 | ¥1,230.00 | 询底价 |
500 mg | 756875-51-1 | ¥9,830.00 | 询底价 |
100 mg | 756875-51-1 | ¥4,870.00 | 询底价 |
5 mg | 756875-51-1 | ¥828.00 | 询底价 |
25 mg | 756875-51-1 | ¥2,480.00 | 询底价 |
2 mg | 756875-51-1 | ¥490.00 | 询底价 |
Product Introduction
Bioactivity
英文名: K6PC-5
描述: K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels. With its potential applications in skin diseases associated with abnormal keratinocyte function, as well as in studies on neurodegeneration and virus infection, K6PC-5 presents a promising compound for research purposes.
体外活性: K6PC-5 (1-10 μM; 24 h) increases the involucrin and loricrin levels in a dose-dependent manner in normal human epidermal keratinocytes (NHEKs). K6PC-5 promotes differentiation and proliferation of keratinocytes via intracellular Ca2+ signaling. In addition, K6PC-5 stimulates the phosphorylation of p42/44 extracellular signal-regulated kinase and c-Jun N-terminal kinase[1]. K6PC-5 (1-10 μM; 24 h) promotes fibroblasts proliferation and collagen synthesis in human fibroblasts. K6PC-5 induces intracellular Ca2+ concentration ([Ca2+]i) oscillations in human fibroblasts[2]. K6PC-5 (10, 25, and 50 μM; 48 h) significantly attenuates EBOV-induced infection in EBOV-infected EA.hy926 cells. K6PC-5 significantly reduces the virus titers in supernatants of infected cells and strikingly decreased the amount of VP40 in a concentration-dependent manner[3].
体内活性: 在本质上老化的无毛小鼠(56周岁)中,1%的K6PC-5被局部应用2周。这种K6PC-5处理显著增加了真皮成纤维细胞的数量和胶原蛋白的产生。因此,真皮厚度也显著增加[2]。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 90 mg/mL (262 mM)
关键字: K6PC-5
相关产品: Phorbol 12-myristate 13-acetate | SKI V | Ceranib-2 | Ponesimod | SK1-IN-1 | S1p receptor agonist 1 | Fingolimod hydrochloride | W140 HBr | CYM-5541 | PF429242 dihydrochloride
相关库: Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途