利瑞喹尼 T27838
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 143943-73-1 | ¥6,630.00 | 询底价 |
5 mg | 143943-73-1 | ¥2,800.00 | 询底价 |
1 mg | 143943-73-1 | ¥1,120.00 | 询底价 |
50 mg | 143943-73-1 | ¥8,850.00 | 询底价 |
500 mg | 143943-73-1 | ¥24,300.00 | 询底价 |
100 mg | 143943-73-1 | ¥11,900.00 | 询底价 |
10 mg | 143943-73-1 | ¥4,160.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Lirequinil
描述: Lirequinil (Ro 41-3696) 是一种小分子 GABAA 受体激动剂,可用于研究神经系统疾病。
体内活性: In a double-blind, six-way crossover study of the effects on psychomotor performance and memory of single doses of Ro 41-3696 (Lirequinil) (1, 3, 5, and 10 mg), a novel non-benzodiazepine partial agonist at the benzodiazepine receptor, zolpidem (10 mg) and placebo were compared after night-time administration to 12 healthy young male subjects. Psychomotor performance tests (tracking and attention as part of a standardized task battery) were conducted just before and at 1.5 and 8 h after drug intake. The memory test consisted of the recall of a list of 15 words at 8 h after drug intake which had been learned at 1.5 h after intake. At 1.5 h after drug intake 10 mg zolpidem induced markedly larger psychomotor effects than any dose of Ro 41-3696. The effects of 5 and 10 mg Ro 41-3696 and zolpidem were significantly greater than those of placebo (P < 0.05). The following morning, 8 h after drug intake, the slight residual effects of 5 and 10 mg Ro 41-3696 were statistically significantly greater than placebo, whereas zolpidem effects did not differ from placebo. The results of the memory test showed that learning as well as recall was most clearly impaired by zolpidem. An influence of Ro 41-3696 on these variables was not observed for doses up to 5 mg. In conclusion, Ro 41-3696 at all doses tested induced fewer effects on psychomotor performance and memory than 10 mg zolpidem at 1.5 h after intake. However, the effects of Ro 41-3696 appeared to be of longer duration. [2]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (111.37 mM)
关键字: Lirequinil
相关产品: Myristicin | 2'-O-Methylisoliquiritigenin | alpha-Asarone | GAD65(247-266) epitope TFA | Dipropofol | Xilmenolone | 2'MeO6MF | Suriclone | β-Alanine | Cirsimaritin
相关库: Anti-Neurodegenerative Disease Compound Library | Neurotransmitter Receptor Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途