野百合碱 T2803
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
500 mg | 315-22-0 | ¥3,730.00 | 询底价 |
100 mg | 315-22-0 | ¥913.00 | 询底价 |
1 mL | 315-22-0 | ¥250.00 | 询底价 |
50 mg | 315-22-0 | ¥622.00 | 询底价 |
1 g | 315-22-0 | ¥5,450.00 | 询底价 |
25 mg | 315-22-0 | ¥325.00 | 询底价 |
200 mg | 315-22-0 | ¥1,660.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Monocrotaline
描述: Monocrotaline (Crotaline) 是一种吡咯里西啶生物碱,从猪屎豆植物的种子中提取得到,可诱导啮齿动物产生肺动脉高血压。
体外活性: Monocrotaline (MCT) is an 11-membered macrocyclic pyrrolizidine alkaloid (PA) derived from the seeds of the Crotalaria spectabilis plant[1]. Monocrotaline is a natural ligand that exhibits dose-dependent cytotoxicity with potent antineoplastic activity. The in vitro cytotoxicity of monocrotaline is proved at IC50 24.966 µg/mL and genotoxicity at 2 X IC50 against HepG2 cells[2].
体内活性: MCT leads to a pulmonary vascular syndrome in rats characterized by proliferative pulmonary vasculitis, pulmonary hypertension (PH), and cor pulmonale[3]. Among preClinicalal models of pulmonary arterial hypertension (PAH), monocrotaline animal model offers the advantage of mimic several key aspects of human PAH, including vascular remodeling, proliferation of smooth muscle cells, endothelial dysfunction, upregulation of inflammatory cytokines, and right ventricle failure, requiring a single drug injection[4]. Changes in many pathways associated with the development of PH, including activated glycolysis, increased markers of proliferation, disruptions in carnitine homeostasis, increased inflammatory and fibrosis biomarkers, and a reduction in glutathione biosynthesis are observed with the injection of monocrotaline[5].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 55 mg/mL (169.04 mM)
关键字: inhibit | Inhibitor | Monocrotaline
相关产品: TGFβRI-IN-3 | Vactosertib | Chebulinic acid | Dalbergioidin | SRI-011381 hydrochloride | BIO-013077-01 | EW-7195 | LDN-193189 2HCl | Elezanumab | Rubrofusarin gentiobioside
相关库: Drug Repurposing Compound Library | Anti-Liver Cancer Compound Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Bioactive Compounds Library Max | Chinese Pharmacopoeia Natural Product Library | Anti-Cancer Clinical Compound Library | Traditional Chinese Medicine Monomer Library | TGF-beta/Smad Compound Library | Reprogramming Compound Library
野百合碱 T2803信息由TargetMol中国为您提供,如您想了解更多关于野百合碱 T2803报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途