化合物Ralaniten T28502

Product Introduction
Bioactivity


英文名: Ralaniten

描述: Ralaniten (EPI-002) 是一种具有有效性、特异性和口服活性的雄激素受体 N 端结构域 (AR-NTD) 拮抗剂。Ralaniten 对 AR 转录活性有抑制作用，IC50 值为 7.4 μM。Ralanites 具有抗癌活性，可用于研究去势抵抗性前列腺癌 (CRPC) 。

体外活性: Ralaniten(5-35 μM; 2-3 days) reduces AR-dependent proliferation of LNCaP cells and has no effect on the viability of PC3 human prostate cancer cells that do not express functional AR.[1]Ralaniten (10-35 μM; 4 hours) inhibits forskolin-induced transactivation of the AR N-terminal domain (NTD) in LNCaP cells.[1]

体内活性: Ralaniten (100 mg/kg; taken orally twice daily for 28 days; Male NOD-SCID mice bearing subcutaneous tumors were castrated) inhibits VCaP tumor growth in castrated mice.[1]

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 90 mg/mL (227.91 mM)


关键字: EPI 002 | Ralaniten | EPI002

相关产品: AR antagonist 1 | CSRM617 hydrochloride | Zanoterone | Protodioscin | Topterone | Enzalutamide carboxylic acid | N-Desmethyl-Apalutamide | Galloylpaeoniflorin | Adrenosterone | UT-34

相关库: Bioactive Compounds Library Max | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途