表儿茶素 T2856

Product Introduction
Bioactivity


英文名: (-)-Epicatechin

描述: (-)-Epicatechin (Epicatechin) 是一种 COX-1 的抑制剂，通过阻断 NF-κB 的 p65 亚基的核定位来抑制 IL-1β 诱导的 iNOS 表达。

细胞实验: Panc-1 cells are seeded into T-150 flasks and on the next day, cells are treated with different concentrations of (-)-epicatechin for 1 h, then harvested and solubilized in 10 mM HEPES (pH 7.4), 40 mM KCl, 1%Tween-20, 1 μM oligomycin, 1 mM PMSF,10 mM KF, 2 mM EGTA, and 1 mM Na3VO4. COX activity is measured in the presence of 20 mM ascorbate and 200 μM substrate cytochrome c from cow heart.(Only for Reference)

体外活性: (-)-Epicatechin stimulates mitochondrial respiration and oxygen consumption in Panc-1 cells. Human normal fibroblasts are not affected. (-)-Epicatechin sensitizes Panc-1, U87, and MIA PaCa-2 cells with an average radiation enhancement factor (REF) of 1.7, 1.5, and 1.2, respectively. (-)-Epicatechin does not sensitize normal fibroblast cells to ionizing radiation with a REF of 0.9, suggesting cancer cell selectivity. (-)-Epicatechin enhances Chk2 phosphorylation and p21 induction when combined with radiation in cancer, but not normal cells[2].

体内活性: Aging has deleterious effects on modulators of muscle growth/differentiation, the consumption of modest amounts of the flavanol (?)-epicatechin can partially reverse these changes. In mice, myostatin and senescence-associated β-galactosidase levels increase with aging, while those of follistatin and Myf5 decrease. (?)-Epicatechin decreases myostatin and β-galactosidase and increases levels of markers of muscle growth. In humans, myostatin and β-galactosidase increase with aging while follistatin, MyoD and myogenin decrease. Treatment for 7 days with (?)-epicatechin increases hand grip strength and the ratio of plasma follistatin/myostatin[1]. Low-dose (?)-epicatechin treatment resulted in significant increases in skeletal muscle capillarity, mitochondrial biogenesis, and oxidative enzyme activity, which corresponded to lower muscle fatigue and higher endurance capacity when compared to the placebo group. (?)-epicatechin may potentially regulate the protein expression between angiogenic and antiangiogenic factors, such as VEGF-A and TSP-1, respectively[3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : < 1 mg/mL (insoluble or slightly soluble)
H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 45 mg/mL (155.02 mM)


关键字: Epicatechol | epi-Catechin | Endogenous Metabolite | Inhibitor | Ferroptosis | COX | inhibit | ( ) Epicatechin | Cyclooxygenase | ()Epicatechin

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相关库: Drug Repurposing Compound Library | Marine Natural Product Library | Tobacco Monomer Library | Anti-Cancer Drug Library | Selected Plant-Sourced Compound Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | Traditional Chinese Medicine Monomer Library | Miao medicine Compound Library | Antiparasitic Natural Product Library

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